Knowledge Sharing Center
Your Portal to Orthopedic Insights
Open Knowledge Hub
Explore a wealth of publicly accessible resources and insights, offering valuable knowledge.
OrthoTalk [members-only area]
A unique community where leading experts and members collaborate, share, and learn together, driving innovation in bone regeneration.
Glossary
Navigate the world of bone health and regeneration with our entry-level glossary.
Articles
Dive into thought-provoking articles that explore the latest trends in bone research .
Videos
Watch insightful videos shading light on various bone-related issues.
Social Sources
See some other groups sharing the knowledge.
The OrthotTreat Lab
Our latest studies, papers, opinions and publications.
Findings & Insights
Gain exclusive access to our scientific results.
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OrhtoTreat Spotlight
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Open Knowledge Hub
Glossary
Navigate the world of bone regeneration with our glossary, defining key terms and concepts.
Active Pharmaceutical Ingredients (APIs)
The biologically active components in pharmaceuticals, crucial in OrthoTreat’s dual-drug therapy for bone healing.
Antagonistic Effect
A phenomenon where one substance inhibits or counteracts the effect of another, important in drug interactions.
β-caryophyllene [BCP]
A compound acting as a selective CB2 receptor agonist, promoting bone mineralization and inhibiting processes like adipogenesis and osteoclastogenesis.
Blood Flow Enhancement
The improvement of blood circulation, which is vital for nutrient delivery and waste removal in bone tissue, often enhanced by treatments like statins.
Blood Vessels
Tubular structures that carry blood throughout the body, including bones, essential for supplying oxygen and nutrients necessary for bone health and repair.
Bone Fractures
Breaks or cracks in bones, which are a primary focus of OrthoTreat’s regenerative therapies.
Bone Health
The overall condition of bones, influenced by various factors including cellular activity and treatments like statins that affect bone turnover and regeneration.
Bone Metabolism
Refers to the processes involved in maintaining bone tissue balance, including formation and resorption phases critical in bone regeneration.
Bone Remodeling Phases
- Inflammatory Phase: Initial response to fracture involving blood clot formation and inflammatory mediators that prepare the site for healing.
- Reparative Phase: Characterized by callus formation and new bone development around the fracture site.
- Remodeling Phase: The final stage where the bone structure is refined to restore normal shape and function.
Dual-Drug Therapy
A treatment approach using two active pharmaceutical ingredients to enhance therapeutic outcomes, particularly in bone healing applications.
Lovastatin (LOV)
A lipid-lowering medication from the statin class that positively affects bone healing and regeneration. It works by controlling the expression of important proteins and biochemical pathways involved in osteogenesis. Lovastatin has been shown to stimulate osteogenic differentiation and inhibit adipogenic differentiation, contributing to increased bone formation.
ModulX®
OrthoTreat’s proprietary dual-drug therapy formulation designed to accelerate bone healing through controlled release mechanisms across all phases of fracture healing.
Osteoblasts
Cells responsible for new bone formation. They synthesize bone matrix and are essential for the growth and maintenance of bones.
Osteoclasts
Cells that break down bone tissue, playing a crucial role in bone remodeling and calcium homeostasis by resorbing bone matrix.
Osteointegration (Osseointegration)
The process of creating a direct structural and functional connection between living bone and the surface of an implant. This is critical for implant stability, achieved through a series of cellular and molecular events that lead to new bone formation around the implant.
Osteoporosis
A condition characterized by weakened bones due to decreased bone mass and density, leading to an increased risk of fractures. It involves an imbalance between osteoblasts and osteoclasts activity.
Osteoregulation
A new term coined by OrthoTreat referring to the regulation of bone growth, remodeling, and repair processes. This involves a balance between osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells).
RANK/RANKL Pathway
RANK (Receptor Activator of Nuclear Factor κB) is a receptor on osteoclasts that binds to RANKL (RANK Ligand), a protein essential for osteoclast differentiation and activation. This pathway is crucial for regulating bone remodeling and is a target for osteoporosis treatments.
Synergistic Effect
When two or more substances or actions produce a combined effect greater than the sum of their separate effects. In the context of OrthoTreat’s therapies, synergistic effects are sought to enhance bone healing outcomes.
Articles
Dive into thought-provoking articles that explore the latest trends and advancements in orthopedics.
Approaches to Bone Regeneration
Cells in the Inflammatory Microenvironment via the CB2-dependent p38 MA
Videos
Watch insightful videos featuring expert talks and demonstrations on cutting-edge orthopedic techniques.
Bone remodeling and modeling
How does broken bone heal?
Bone remodeling and repair
How Does A Bone Break Heal Bone Fracture Healing Process
Bone cells and bone formation
How Bone Marrow Keeps You Alive
What Happens When Bone Regeneration Goes Wrong
BONE STRUCTURE
Social sources
See some other groups sharing the knowledge
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AAOM-American Association of Orthopedic Medicine
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Foundations
These organizations are at the forefront of research, education, and advocacy in their respective fields, contributing significantly to global orthopedic, osteoporosis, and osseointegration advancements.
Orthopaedic Trauma Association (OTA)
World Orthopaedic Concern (WOC)
Asia Pacific Orthopaedic Association (APOA)
American Academy of Orthopaedic Surgeons (AAOS)
American Orthopaedic Association (AOA)
Orthopaedic Research and Education Foundation (OREF)
American Orthopaedic Society for Sports Medicine (AOSSM)
Osteoporosis Organizations
American Society for Bone and Mineral Research (ASBMR) A professional, scientific society that brings together clinical and experimental scientists involved in the study of bone and mineral metabolism.
Osseointegration Organizations
International Society for Clinical Osseointegration (ISCO) Focuses on the promotion and advancement of the science and clinical practice of osseointegration.
Osseointegration Foundation (OF) Promotes research and education in osseointegration and supports advancements in clinical practice.
