Long bone fractures
Bone metabolism 101
3 phases to bone regeneration:
An inflammatory, reparative, and remodeling phase
- 1. Inflammatory phase
- 2. Reparative phase
- 3. Remodeling phase
1. Inflammatory phase
Fracture results in torn blood vessels and the formation of a blood clot or hematoma.
The inflammatory reaction results in the release of cytokines, growth factors and prostaglandins, all of which are important in healing.
The fracture hematoma becomes organized and is then infiltrated by fibrovascular tissue, which forms a matrix for bone formation and primary callus.
2. Reparative phase
A thick mass of callus forms around the bone ends, from the fracture hematoma. Bone-forming cells are recruited from several sources to form new bone. Soft callus is organized and remodeled into hard callus over several weeks. Soft callus is elastic and can easily deform or bend if the fracture is not adequately supported.
3. Remodeling phase
The healed fracture and surrounding callus respond to activity, external forces, functional demands and growth. Bone (external callus) which is no longer needed is removed and the fracture site is smoothed and sculpted until it returns to normal appearance.
- 1
- 2
- 3
1. Inflammatory phase
Fracture results in torn blood vessels and the formation of a blood clot or hematoma.
The inflammatory reaction results in the release of cytokines, growth factors and prostaglandins, all of which are important in healing.
The fracture hematoma becomes organized and is then infiltrated by fibrovascular tissue, which forms a matrix for bone formation and primary callus.
2. Reparative phase
A thick mass of callus forms around the bone ends, from the fracture hematoma. Bone-forming cells are recruited from several sources to form new bone. Soft callus is organized and remodeled into hard callus over several weeks. Soft callus is elastic and can easily deform or bend if the fracture is not adequately supported.
3. Remodeling phase
The healed fracture and surrounding callus respond to activity, external forces, functional demands and growth. Bone (external callus) which is no longer needed is removed and the fracture site is smoothed and sculpted until it returns to normal appearance.
ModulX® accelerates optimal healing throughout all 3-phases of the healing process
Unmet Need
Trauma related Fractures
Economic burden:
“Bone fractures are a public health issue around the world and pose a serious economic burden… Fractures can lead to work absence, decreased productivity, disability, impaired quality of life, health loss, and high health-care costs.”
In Humans :
Prevalence: 455 million
Incidence: 127 million [2019]
Prevalence: 455 million
Incidence: 127 million [2019]
Clinical effect:
- Malunion and Nonunion Fractures
- PAIN
- Impaired mobility
Unmet Need
Trauma related Fractures
Economic burden:
“Bone fractures are a public health issue around the world and pose a serious economic burden… Fractures can lead to work absence, decreased productivity, disability, impaired quality of life, health loss, and high health-care costs.”
In Humans :
Prevalence: 455 million
Incidence: 127 million [2019]
Prevalence: 455 million
Incidence: 127 million [2019]
Clinical effect:
- Malunion and Nonunion Fractures
- PAIN
- Impaired mobility
Unmet Need
Trauma related Fractures
Economic burden:
“Bone fractures are a public health issue around the world and pose a serious economic burden… Fractures can lead to work absence, decreased productivity, disability, impaired quality of life, health loss, and high health-care costs.”
In Humans :
Prevalence: 455 million
Incidence: 127 million [2019]
Prevalence: 455 million
Incidence: 127 million [2019]
Clinical effect:
- Malunion and Nonunion Fractures
- PAIN
- Impaired mobility
In Veterinary : ~2.4 million dogs and 0.5 million cats have been classified as having bone fracture in US 2 [2019]
- Unlike the situation in humans, a dog or cat cannot be relied on to rest the limb properly, and any bandaging has the potential to cause serious complications. As a result, most animals are best treated with an operation.
The Market
178 Million new bone-fracture injuries occur annually worldwide
In the Pipeline
Humans
Animals
Health companies
Fractures and Trauma
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Magnitude:
Fractures and trauma represent significant global health burdens, impacting millions annually. -
Challenges:
Prolonged recovery periods, nonunion and malunion fractures, and post-surgical complications. -
OrthoTreat’s Response:
With ModulX, we target accelerated healing of bone fractures, reducing complications and promoting faster recovery.
Onco -Orthopedics
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Magnitude:
As the number of cancer survivors grows, so does the concern for bone health among these patients. -
Challenges:
Bone metastasis, increased fracture risk, and skeletal-related events in cancer patients. -
OrthoTreat’s Response:
We aim to explore treatments that will enhance recovery and improve outcomes for cancer patients facing unique bone health challenges.
Osseointegration
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Magnitude:
Dental and prosthesis implant procedures are common, with millions seeking treatments annually. -
Challenges:
Delayed healing after procedures, complications in osseointegration leading to implant failures, and post-operative discomfort. -
OrthoTreat’s Response:
By adapting our groundbreaking treatments for osseointegration applications, we aim to offer faster healing processes and greater success rates in implant procedures.
Osteoporosis
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Magnitude:
Osteoporosis affects over 200 million people worldwide, leading to over 8.9 million fractures annually. -
Challenges:
Diminished bone strength, recurrent fractures, and a substantial decrease in quality of life for patients. -
OrthoTreat’s Response:
Leverage our expertise to create prophylactic treatments, lowering the risk of osteoporotic fractures and improving overall bone health.
